Science says it can predict in the short term and it certainly can, but its snorting preoccupation with the short term prevents it from seeing the dystopian outcome of its utter unpredictability in the long term.
I believe the first thing humans should do is gradually shut down all machines, and abolish the wheel, to prevent all distance travel and global and even regional trade, so the ecosystems can reestablish themselves.
All humans should settle in a place away from the cities, so that humanity is meaningfully distributed for future local survival. Eventually humans should generally not move more than 100 miles from where they were born.
All cities should be imploded, and humans should build huts a small distance away from it, for only a small portion of its former inhabitants, to still take advantage of the prime locations. Most current city-dwellers should go far away from their city, because city life and even town life would forever be a thing of the past. Nature would quickly overgrow the ruins of the cities. Fertile dust would blow onto the well-pulverized ruins, to gradually become soil where plants could naturally grow as if against hills.
This change should happen very gradually and as agreed in the finer specifics, between humans who are in principle intent on emotionally understanding each other, instead of adherents of the current culture of promoting antithetical debate. But we have no choice but to shut down the metaphysics of technology as well as technology itself. Or we are extinct. We have no choice. Whether you believe it now or not, you will surely as your are reading here, believe it soon; and then it may be too late.